LEXIVA.com. Information about LEXIVA for patients and caregivers

Everyone's day has a different playlist: work, family commitments, keeping fit. HIV meds are just one part of it.

LEXIVA, a protease inhibitor taken with other HIV medications, has benefits that might make it a convenient way to help manage HIV.

LEXIVA can now be taken with less ritonavir than before. It's only 3 pills once a day if you haven't taken a protease inhibitor before. If you have taken a protease inhibitor, LEXIVA can be taken twice a day.

Ask your healthcare provider if LEXIVA is right for you.

Like all HIV medicines, LEXIVA does not cure HIV infection/AIDS or prevent passing HIV to others.

See the full Prescribing Information for LEXIVA

LEXIVA ® (fosamprenavir calcium)

Indication and Usage:

LEXIVA treats HIV infection in adults. It should always be used in combination with other HIV medicines. These medicines do not cure HIV infection/AIDS or prevent passing HIV to others.

Important Safety Information

You should not take LEXIVA if you have had an allergic reaction to LEXIVA or AGENERASE ® (amprenavir)
High blood sugar, diabetes or worsening of diabetes, and bleeding in hemophiliacs have occurred in some patients taking protease inhibitors
When you start taking HIV medicines, your immune system may get stronger and could begin to fight infections that have been hidden in your body, such as pneumonia, herpes virus, or tuberculosis. If you have new symptoms after starting your HIV medicines, be sure to tell your doctor
Changes in body fat may occur in some patients taking antiretroviral therapy. The cause and long-term health effects of these conditions are not known at this time
Skin rashes can occur in patients taking LEXIVA. Rarely, rashes were severe or life threatening
Opportunistic infections can develop when you have HIV and your immune system is weak. It is very important that you see your healthcare provider regularly while you are taking LEXIVA to discuss any side effects or concerns
Most common side effects in clinical studies were diarrhea, headache, nausea, rash, and vomiting. In most cases, these side effects did not cause people to stop taking their medicine

Drug Interactions

LEXIVA should not be taken with: AGENERASE ® (amprenavir), Halcion ® (triazolam), ergot medications (Cafergot ® , Migranal ® , D.H.E. 45 ® , and others), Propulsid ® (cisapride), Versed ® (midazolam), Orap ® (pimozide), Zocor ® (simvastatin), Mevacor ® (lovastatin), Rifadin ® (rifampin), Rescriptor ® (delavirdine mesylate), or St. John's wort (Hypericum perforatum). If you are taking Norvir ® (ritonavir), you should not take Tambocor ® (flecainide) or Rythmol ® (propafenone hydrochloride)
Serious and/or life-threatening events could occur between LEXIVA and other medications, including Cordarone ® (amiodarone), lidocaine (intravenous only), Elavil ® (amitriptyline HCl) and Tofranil ® (imipramine pamoate), tricyclic antidepressants, and Quinaglute ® (quinidine)
Women who use birth control pills should choose a different kind of birth control. The use of LEXIVA with Norvir (ritonavir) in combination with birth control pills may hurt your liver. Also, birth control pills may not work if you take LEXIVA or LEXIVA with Norvir. Talk to your healthcare provider about choosing the right birth control for you
Patients taking Viagra ® (sildenafil citrate) or LEVITRA ® (vardenafil HCl) with LEXIVA may be at an increased risk of side effects
This list of drug interactions is not complete. Be sure to tell your healthcare provider about all medicines you are taking or plan to take, including over-the-counter drugs, vitamins, and herbals

Resistance

Missing or skipping doses of your medicine may make it easier for the virus to mutate and multiply. Your medicines may not work as well against a mutated virus and you may become cross-resistant to other HIV medicines. It’s important to take your medicine exactly as prescribed

With the exception of LEXIVA, AGENERASE, and LEVITRA, the brands listed are trademarks of their respective owners and are not trademarks of GlaxoSmithKline. The makers of these brands are not affiliated with and do not endorse GlaxoSmithKline or its products.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.